CAPRIN1 and RAG2

Data Source:
BioGRID (proximity labelling technology)

		CAPRIN1	RAG2
Description		cell cycle associated protein 1	recombination activating 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Synapse	Nucleoplasm DNA Recombinase Complex
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Methylated Histone Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Translation Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis	B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment Chromatin Organization Protein Ubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination Defense Response To Bacterium Positive Regulation Of Organ Growth
Pathways			Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Iron status biomarkers (transferrin saturation) ( 28334935) Systolic blood pressure ( 30224653)	Rheumatoid arthritis ( 24390342)
Interacting Genes		6 interacting genes: APP DAPK1 MFHAS1 PIN1 PRMT1 WBP4	3 interacting genes: IPO5 RAG1 SKP2
Entrez ID		4076	5897
HPRD ID		03108	08913
Ensembl ID		ENSG00000135387	ENSG00000175097
Uniprot IDs		Q14444	P55895
PDB IDs		4WBE 4WBP
Enriched GO Terms of Interacting Partners?
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