HSPA12A and M6PR

Data Source:
BioGRID (two hybrid)

		HSPA12A	M6PR
Description		heat shock protein family A (Hsp70) member 12A	mannose-6-phosphate receptor, cation dependent
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Exosome	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Protein Binding ATP Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding
	Biological Process	Biological_process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization
Pathways		Regulation of HSF1-mediated heat shock response	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 26426971) Bone mineral density (hip) ( 30172743) Colorectal cancer ( 23263487) Freckles ( 29895819) Systolic blood pressure ( 30224653 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)	SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)
Interacting Genes		5 interacting genes: HRAS HSPA12B M6PR NRCAM SORL1	12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID		259217	4074
HPRD ID		19074	01106
Ensembl ID		ENSG00000165868	ENSG00000003056
Uniprot IDs		A0A1B0GTF3 A0A6I8PIT5 A0A6I8PLB1 B7Z2M8 O43301	F5GX30 P20645
PDB IDs			1JUQ
Enriched GO Terms of Interacting Partners?
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