LTBR and DIABLO

Data Source:
HPRD (in vitro, in vivo)

		LTBR	DIABLO
Description		lymphotoxin beta receptor	diablo IAP-binding mitochondrial protein
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	42 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBE2K UFM1 XIAP ZNF746
Entrez ID		4055	56616
HPRD ID		02988	05560
Ensembl ID		ENSG00000111321	ENSG00000184047
Uniprot IDs		P36941	A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs		1RF3 4MXW	1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6
Enriched GO Terms of Interacting Partners?
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