LSP1 and ACTG1

Data Source:
HPRD (in vitro)

		LSP1	ACTG1
Description		lymphocyte specific protein 1	actin gamma 1
Image
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Apical Junction Complex Extracellular Exosome Blood Microparticle Dense Body
	Molecular Function	Actin Binding	Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Cellular Defense Response Signal Transduction	Angiogenesis Morphogenesis Of A Polarized Epithelium Retina Homeostasis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Cell Junction Assembly Maintenance Of Blood-brain Barrier Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Membrane Organization Platelet Aggregation Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Protein Localization To Bicellular Tight Junction
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			Copper Artenimol
Diseases
GWAS		Bladder cancer ( 24163127) Breast cancer ( 29059683 17529967 23535729 27117709 20453838) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Central corneal thickness ( 32528159) Diastolic blood pressure ( 27841878 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Potassium levels ( 29403010) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 29403010 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)	Hand grip strength ( 29313844) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: ACTG1 BMPR2 GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP	68 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WIPF1
Entrez ID		4046	71
HPRD ID		01083	00017
Ensembl ID		ENSG00000130592	ENSG00000184009
Uniprot IDs		A8K7L8 P33241	P63261
PDB IDs		3BH8 4NO0 4NO2	5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2
Enriched GO Terms of Interacting Partners?
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