LRPAP1 and PPM1G

Data Source:
HPRD (two hybrid)

		LRPAP1	PPM1G
Description		LDL receptor related protein associated protein 1	protein phosphatase, Mg2+/Mn2+ dependent 1G
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Rough Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Protein Binding Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cell Death Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Signaling Receptor Activity	Protein Dephosphorylation Cell Cycle Arrest Peptidyl-threonine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Bone mineral density (total hip) ( 29883787) Creatinine levels ( 31015462) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Non-oily fish consumption ( 32066663) Takayasu arteritis ( 25604533) Triglyceride levels ( 31928498)
Interacting Genes		18 interacting genes: ASPH ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR	10 interacting genes: FBXO38 GRIA3 H3-4 LRPAP1 MSL1 MTNR1B RPS6KA1 TERF1 TERF2 TERF2IP
Entrez ID		4043	5496
HPRD ID		00082	09237
Ensembl ID		ENSG00000163956	ENSG00000115241
Uniprot IDs		P30533	O15355 Q6IAU5
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03
Enriched GO Terms of Interacting Partners?
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