VWA5A and SPSB1

Data Source:
BioGRID (two hybrid)

		VWA5A	SPSB1
Description		von Willebrand factor A domain containing 5A	splA/ryanodine receptor domain and SOCS box containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process		Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aging (time to death) ( 21782286)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		6 interacting genes: APP MEOX2 PPARA PRTFDC1 RHOU SPSB1	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		4013	80176
HPRD ID		04238	18106
Ensembl ID		ENSG00000110002	ENSG00000171621
Uniprot IDs		A0A024R3H3 O00534	A0A024R4G8 Q96BD6
PDB IDs			2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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