ARHGDIG and RHOG

Data Source:
HPRD (two hybrid)

		ARHGDIG	RHOG
Description		Rho GDP dissociation inhibitor gamma	ras homolog family member G
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Blastocyst Hatching Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Protein Localization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Neutrophil Degranulation Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Rho GTPase cycle	GPVI-mediated activation cascade PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		12 interacting genes: AGTR1 BICRAL CDC42 CEP170P1 KXD1 MED10 RAC1 RHOA RHOB RHOG RHOH TACC3	21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		398	391
HPRD ID		04163	01537
Ensembl ID		ENSG00000242173	ENSG00000177105
Uniprot IDs		F1T0H7 Q99819	P84095 Q6ICQ8
PDB IDs			6UKA
Enriched GO Terms of Interacting Partners?
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