RHOG and ELMO2

Data Source:
HPRD (in vivo, in vitro)

		RHOG	ELMO2
Description		ras homolog family member G	engulfment and cell motility 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytosol Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Neutrophil Degranulation Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane	Apoptotic Process Actin Filament Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Cell Chemotaxis Cell-cell Adhesion
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3	3 interacting genes: DOCK1 DOCK4 RHOG
Entrez ID		391	63916
HPRD ID		01537	12103
Ensembl ID		ENSG00000177105	ENSG00000062598
Uniprot IDs		P84095 Q6ICQ8	Q96JJ3
PDB IDs		6UKA	6IDX 6IE1
Enriched GO Terms of Interacting Partners?
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