ARHGDIA and SUMO4

Data Source:
HPRD (in vivo)

		ARHGDIA	SUMO4
Description		Rho GDP dissociation inhibitor alpha	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Membrane Extracellular Exosome	Nucleus SUMO Ligase Complex
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Axonal growth inhibition (RHOA activation) Rho GTPase cycle Axonal growth stimulation
Drugs
Diseases
GWAS			Dupuytren's disease ( 28886342)
Interacting Genes		41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		396	387082
HPRD ID		03565	10584
Ensembl ID		ENSG00000141522	ENSG00000177688
Uniprot IDs		J3QQX2 P52565 V9HWE8	Q6EEV6
PDB IDs		1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80
Enriched GO Terms of Interacting Partners?
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