ARHGAP5 and RND3

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vitro, two hybrid, in vivo)

		ARHGAP5	RND3
Description		Rho GTPase activating protein 5	Rho family GTPase 3
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Cell Adhesion Rho Protein Signal Transduction Mammary Gland Development Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Rho GTPase cycle
Drugs			Guanosine-5'-Triphosphate
Diseases
GWAS		Asthma ( 29273806)	Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		11 interacting genes: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2	8 interacting genes: ARHGAP5 C14orf119 CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		394	390
HPRD ID		04060	04233
Ensembl ID		ENSG00000100852	ENSG00000115963
Uniprot IDs		Q13017	B2R838 P61587
PDB IDs		2EE4 2EE5 5U4V	1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?
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