STMN1 and CAMK2G

Data Source:
BioGRID (enzymatic study, genetic interference)

		STMN1	CAMK2G
Description		stathmin 1	calcium/calmodulin dependent protein kinase II gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Membrane Neuron Projection Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Protein Binding Tubulin Binding	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cytokinesis Microtubule Depolymerization Mitotic Spindle Organization Signal Transduction Axonogenesis Brain Development Response To Virus Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Stress Fiber Assembly Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity	Protein Phosphorylation Protein Dephosphorylation Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat
Pathways		Nuclear signaling by ERBB4	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS			Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)
Interacting Genes		17 interacting genes: CAMK2G CDK1 CDKN1B CHEK2 CSNK2A1 ERBB2 FANCC GLP1R HSPA5 HSPA8 MAPK3 PRKACA SEPTIN2 SESTD1 STAT3 UBQLN4 UHMK1	50 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CAMK2A CAMK2B CAMK2D CDC37 CHAT CREM DUS1L EGFR ESRRG FLNA GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		3925	818
HPRD ID		01047	03672
Ensembl ID		ENSG00000117632	ENSG00000148660
Uniprot IDs		A0A140VJW2 P16949	A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3
PDB IDs			2UX0 2V7O
Enriched GO Terms of Interacting Partners?
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