LAMA3 and LAMB3

Data Source:
HPRD (in vitro)

		LAMA3	LAMB3
Description		laminin subunit alpha 3	laminin subunit beta 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Endoplasmic Reticulum Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Laminin Complex Collagen-containing Extracellular Matrix
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-containing Complex Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Integrin-mediated Signaling Pathway Axon Guidance Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion	Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Basement Membrane Assembly
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs		Lanoteplase
Diseases		Laryngoonychocutaneous syndrome Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 22959728) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)	Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)
Interacting Genes		7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1
Entrez ID		3909	3914
HPRD ID		02883	01032
Ensembl ID		ENSG00000053747	ENSG00000196878
Uniprot IDs		A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787	A0A0S2Z3R6 Q13751
PDB IDs
Enriched GO Terms of Interacting Partners?
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