ACAT2 and CDX2

Data Source:
HPRD (in vivo)

		ACAT2	CDX2
Description		acetyl-CoA acetyltransferase 2	caudal type homeobox 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryo Development Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development
Pathways		Cholesterol biosynthesis	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs		S-Hydroxycysteine Coenzyme A
Diseases
GWAS		Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 30108283)	Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		7 interacting genes: AKT1 CDX2 CSNK2A1 LNX1 TERF1 WWOX ZNF76	16 interacting genes: ACAT2 CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB
Entrez ID		39	1045
HPRD ID		00006	02622
Ensembl ID		ENSG00000120437	ENSG00000165556
Uniprot IDs		Q9BWD1	Q99626
PDB IDs		1WL4 1WL5	5LTY 6ES2 6ES3
Enriched GO Terms of Interacting Partners?
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