CDX2 and ACAT2

Data Source:
HPRD (in vivo)

		CDX2	ACAT2
Description		caudal type homeobox 2	acetyl-CoA acetyltransferase 2
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GO Annotations	Cellular Component	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific Double-stranded DNA Binding	Acetyl-CoA C-acetyltransferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryo Development Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development	Lipid Metabolic Process Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process
Pathways		Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Cholesterol biosynthesis
Drugs			S-Hydroxycysteine Coenzyme A
Diseases
GWAS		Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)	Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 30108283)
Interacting Genes		16 interacting genes: ACAT2 CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB	7 interacting genes: AKT1 CDX2 CSNK2A1 LNX1 TERF1 WWOX ZNF76
Entrez ID		1045	39
HPRD ID		02622	00006
Ensembl ID		ENSG00000165556	ENSG00000120437
Uniprot IDs		Q99626	Q9BWD1
PDB IDs		5LTY 6ES2 6ES3	1WL4 1WL5
Enriched GO Terms of Interacting Partners?
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