KNG1 and CPN1

Data Source:
HPRD (in vitro)

		KNG1	CPN1
Description		kininogen 1	carboxypeptidase N subunit 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Metallocarboxypeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Platelet Degranulation Inflammatory Response Negative Regulation Of Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Vasodilation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis	Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Regulation Of Complement Activation Response To Glucocorticoid
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc ORE-1001 Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Adiponectin levels ( 20876611) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Blood protein levels ( 29875488 28240269 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean reticulocyte volume ( 32888494)
Interacting Genes		28 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	6 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1
Entrez ID		3827	1369
HPRD ID		01970	09120
Ensembl ID		ENSG00000113889	ENSG00000120054
Uniprot IDs		P01042	P15169
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y	2NSM
Enriched GO Terms of Interacting Partners?
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