ARF6 and MT2A

Data Source:
BioGRID (pull down)

		ARF6	MT2A
Description		ADP ribosylation factor 6	metallothionein 2A
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Thioesterase Binding Protein N-terminus Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Nervous System Development Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		37 interacting genes: AGAP1 AP1B1 AP3B1 AP3D1 AP3S2 APBB1 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SPAG9 ZNF709	19 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25
Entrez ID		382	4502
HPRD ID		02714	08863
Ensembl ID		ENSG00000165527	ENSG00000125148
Uniprot IDs		P62330	P02795
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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