MT2A and ADAMTS4

Data Source:
HPRD (two hybrid)

		MT2A	ADAMTS4
Description		metallothionein 2A	ADAM metallopeptidase with thrombospondin type 1 motif 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		19 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		4502	9507
HPRD ID		08863	04853
Ensembl ID		ENSG00000125148	ENSG00000158859
Uniprot IDs		P02795	O75173
PDB IDs		1MHU 2MHU	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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