KEL and EDN2

Data Source:
HPRD (in vivo)

		KEL	EDN2
Description		Kell metallo-endopeptidase (Kell blood group)	endothelin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Hormone Activity Endothelin B Receptor Binding
	Biological Process	Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport	Prostaglandin Biosynthetic Process Temperature Homeostasis Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Calcium-mediated Signaling Neutrophil Chemotaxis Macrophage Activation Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Energy Homeostasis
Pathways		Peptide ligand-binding receptors	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Phosphoramidon
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252)	Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK	3 interacting genes: CMA1 KEL MME
Entrez ID		3792	1907
HPRD ID		00194	07173
Ensembl ID		ENSG00000197993	ENSG00000127129
Uniprot IDs		A0A077QP03 P23276	P20800
PDB IDs
Enriched GO Terms of Interacting Partners?
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