EDN2 and KEL

Data Source:
HPRD (in vivo)

		EDN2	KEL
Description		endothelin 2	Kell metallo-endopeptidase (Kell blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity Endothelin B Receptor Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Temperature Homeostasis Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Calcium-mediated Signaling Neutrophil Chemotaxis Macrophage Activation Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Energy Homeostasis	Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors
Drugs			Phosphoramidon
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)	Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252)
Interacting Genes		3 interacting genes: CMA1 KEL MME	12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK
Entrez ID		1907	3792
HPRD ID		07173	00194
Ensembl ID		ENSG00000127129	ENSG00000197993
Uniprot IDs		P20800	A0A077QP03 P23276
PDB IDs
Enriched GO Terms of Interacting Partners?
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