KCNQ1 and KCNE4

Data Source:
HPRD (in vivo)

		KCNQ1	KCNE4
Description		potassium voltage-gated channel subfamily Q member 1	potassium voltage-gated channel subfamily E regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Ion Channel Complex Membrane Raft	Voltage-gated Potassium Channel Complex Apical Plasma Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Phosphatase 1 Binding Outward Rectifier Potassium Channel Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Inner Ear Development Intestinal Absorption Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gastric Acid Secretion Cardiac Conduction Renal Absorption Cellular Response To CAMP Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Circulatory System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole Bepridil Dronedarone Azimilide ICA-105665 Isavuconazole	Enflurane Promethazine Miconazole
Diseases		Type II diabetes mellitus Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome
GWAS		Birth weight ( 31043758) Blood pressure measurement (high sodium intervention) ( 24165912) Blood sugar levels ( 29403010) Body mass index ( 29381148 24861553 28892062) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063 25055868) Estimated glomerular filtration rate ( 31152163 31451708 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 28898252) Gout ( 25967671) Height ( 28552196 20881960 25282103 25429064 31562340) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperuricemia ( 29124443) Long QT syndrome ( 32429735) Malaria ( 31844061) Medication use (drugs used in diabetes) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Offspring birth weight ( 31043758) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet aggregation ( 20526338) Platelet count ( 32888494) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409 29874175) Serum uric acid levels ( 29124443) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Type 2 diabetes ( 32794382 21573907 22885922 24509480 24101674 30054458 18711366 18711367 26961502 25102180 30297969 28254843 26818947 21799836 28406950 23945395 31118516 22961080 32499647 20581827 19401414 24390345 30718926 28869590 20174558) Urate levels ( 31578528) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 28552196)	Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		7 interacting genes: AKAP9 KCNE1 KCNE2 KCNE4 PPP1CA PRKACA TRAF6	10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX
Entrez ID		3784	23704
HPRD ID		06341	09689
Ensembl ID		ENSG00000053918
Uniprot IDs		P51787 Q96AI9	A5H1P5 Q8WWG9
PDB IDs		3BJ4 3HFC 3HFE 4UMO 4V0C 6MIE 6UZZ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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