KCNE4 and OBSL1

Data Source:
BioGRID (two hybrid)

		KCNE4	OBSL1
Description		potassium voltage-gated channel subfamily E regulatory subunit 4	obscurin like cytoskeletal adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Potassium Channel Complex Apical Plasma Membrane	Cytoplasm Golgi Apparatus Centrosome Cytosol Intercalated Disc Z Disc M Band Synapse Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Protein Binding Cytoskeletal Anchor Activity
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Microtubule Cytoskeleton Organization Cytoskeleton Organization Golgi Organization Regulation Of Mitotic Nuclear Division Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Retina Layer Formation Protein Localization To Golgi Apparatus Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Cardiac Myofibril Assembly
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Neddylation
Drugs		Enflurane Promethazine Miconazole
Diseases			3M syndrome
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX	5 interacting genes: HSPB1 KCNE4 LTB4R2 MCPH1 TNS2
Entrez ID		23704	23363
HPRD ID		09689	19306
Ensembl ID			ENSG00000124006
Uniprot IDs		A5H1P5 Q8WWG9	O75147 Q9H8B3
PDB IDs			2CPC 2E6P 2E6Q 2LU7 2LVC 2WP3 2WWK 2WWM 3KNB 5FM5
Enriched GO Terms of Interacting Partners?
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