KCNK2 and MARK1

Data Source:
BioGRID (proximity labelling technology)

		KCNK2	MARK1
Description		potassium two pore domain channel subfamily K member 2	microtubule affinity regulating kinase 1
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Neuronal Cell Body Calyx Of Held Astrocyte Projection	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite
	Molecular Function	Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cardiac Ventricle Development G Protein-coupled Receptor Signaling Pathway Memory Response To Mechanical Stimulus Positive Regulation Of Cell Death Stabilization Of Membrane Potential Response To Axon Injury Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of DNA Biosynthetic Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization
Pathways		TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
Drugs		Dofetilide Dronedarone	Fostamatinib
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lung function (FVC) ( 30061609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes			10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2
Entrez ID		3776	4139
HPRD ID		04450	07353
Ensembl ID		ENSG00000082482	ENSG00000116141
Uniprot IDs		O95069 Q6ZW95 U3N6F0 U3N834	A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4
PDB IDs		4TWK	2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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