TBC1D10C and KLHL12

Data Source:
BioGRID (two hybrid, two hybrid)

		TBC1D10C	KLHL12
Description		TBC1 domain family member 10C	kelch like family member 12
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Filopodium Membrane Ficolin-1-rich Granule Membrane	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Negative Regulation Of B Cell Activation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Activation Of GTPase Activity Regulation Of Cilium Assembly	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Neutrophil degranulation TBC/RABGAPs	Degradation of DVL
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		7 interacting genes: APP HOXA1 KLHL12 KRTAP13-1 KRTAP5-9 NOTCH2NLA PPP3R2	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		374403	59349
HPRD ID		13330	13925
Ensembl ID		ENSG00000175463	ENSG00000117153
Uniprot IDs		Q8IV04	Q53G59 Q9H7R2
PDB IDs			2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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