JUNB and BDNF

Data Source:
BioGRID (two hybrid)

		JUNB	BDNF
Description		JunB proto-oncogene, AP-1 transcription factor subunit	brain derived neurotrophic factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Transcription Factor AP-1 Complex	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Synaptic Vesicle Nuclear Speck Axon Dendrite Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Vasculogenesis Osteoblast Differentiation Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Osteoclast Differentiation Osteoblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Regulation Of Cell Cycle Embryonic Process Involved In Female Pregnancy Labyrinthine Layer Blood Vessel Development Cellular Response To Calcium Ion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Nervous System Development Axon Guidance Synapse Assembly Peripheral Nervous System Development Memory Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Receptor Binding Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription NGF-stimulated transcription	MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			CX-717 Copper Chondroitin sulfate Esketamine
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS			Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 29381148 23563607 19079260 26961502 24861553 31453325 28892062 25673413 20935630 29273807 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 21708048 23563607) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)
Interacting Genes		39 interacting genes: APLP2 ATF4 BATF BATF2 BCL6 BDNF BRCA1 DDIT3 DNMT3L EP300 ESR1 FOS FOSB FOSL1 FOSL2 HOXA7 ITCH JDP2 MAP2 MAPK14 MAPK6 MAPK8 MAPK9 NEU1 NFE2L1 NINL PKIA SAT1 SET SMAD3 SMAD4 SMURF1 TCERG1 TDG UBA6 UBE2I USP24 ZNF595 ZSWIM9	19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1
Entrez ID		3726	627
HPRD ID		01303	00214
Ensembl ID		ENSG00000171223	ENSG00000176697
Uniprot IDs		P17275 Q5U079	A0A0E3SU01 P23560
PDB IDs			1B8M 1BND
Enriched GO Terms of Interacting Partners?
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