ITPKA and CAMK2B

Data Source:
HPRD (in vivo)

		ITPKA	CAMK2B
Description		inositol-trisphosphate 3-kinase A	calcium/calmodulin dependent protein kinase II beta
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendritic Spine	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function	Inositol Hexakisphosphate Kinase Activity Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Small GTPase Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Inositol Metabolic Process Protein Phosphorylation Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Regulation Of Synaptic Plasticity Positive Regulation Of Dendritic Spine Morphogenesis Dendritic Spine Maintenance	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration
Pathways		Synthesis of IP3 and IP4 in the cytosol	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Inositol 1,3,4,5-Tetrakisphosphate 1D-myo-inositol 1,4,5-trisphosphate Phosphoaminophosphonic Acid-Adenylate Ester	[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 23128233)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA	56 interacting genes: ACOT7 ACTN4 AP5B1 ARSA ATXN1 CAMK2A CAMK2D CAMK2G CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5
Entrez ID		3706	816
HPRD ID		00941	12127
Ensembl ID		ENSG00000137825	ENSG00000058404
Uniprot IDs		P23677	A4D2J9 B7Z1Z6 Q13554
PDB IDs		1W2C 1W2D 1W2F 4UPU	3BHH
Enriched GO Terms of Interacting Partners?
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