EIF3E and IFIT1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		EIF3E	IFIT1
Description		eukaryotic translation initiation factor 3 subunit E	interferon induced protein with tetratricopeptide repeats 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e	Cytoplasm Cytosol Host Cell
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding Protein N-terminus Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Binding	Response To Virus Viral Process Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of Defense Response To Virus Negative Regulation Of Helicase Activity Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Exogenous DsRNA
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		32 interacting genes: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP NDRG1 NSF PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48	4 interacting genes: EIF3E IFIT2 IFIT3 IFIT5
Entrez ID		3646	3434
HPRD ID		03734	00983
Ensembl ID		ENSG00000104408	ENSG00000185745
Uniprot IDs		P60228	P09914
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09	4HOU 5UDI 5UDJ 5UDK 5UDL 5W5H 5W5I 6C6K
Enriched GO Terms of Interacting Partners?
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