INSL3 and RXFP2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		INSL3	RXFP2
Description		insulin like 3	relaxin family peptide receptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding	G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Wound Healing	Oocyte Maturation G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling
Pathways		G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS			Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: C12orf57 RXFP2	2 interacting genes: INSL3 RLN2
Entrez ID		3640	122042
HPRD ID		08854	05976
Ensembl ID		ENSG00000248099	ENSG00000133105
Uniprot IDs		P51460	Q8WXD0
PDB IDs		2H8B 2K6T 2K6U	2M96
Enriched GO Terms of Interacting Partners?
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