INSIG1 and BDKRB1

Data Source:
BioGRID (two hybrid)

		INSIG1	BDKRB1
Description		insulin induced gene 1	bradykinin receptor B1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding Oxysterol Binding	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Leukocyte Migration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Response To Mechanical Stimulus Cell Migration Sensory Perception Of Pain Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)	Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: AQP6 BDKRB1 HMGCR HTR2B PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP	32 interacting genes: C1orf43 CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		3638	623
HPRD ID		03633	02639
Ensembl ID		ENSG00000186480	ENSG00000100739
Uniprot IDs		A0A024RD68 A4D2M9 F5H6P3 O15503	P46663
PDB IDs		4J81
Enriched GO Terms of Interacting Partners?
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