INHBC and ACVR1B

Data Source:
HPRD (in vivo)

		INHBC	ACVR1B
Description		inhibin subunit beta C	activin A receptor type 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Glycoprotein hormones	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs			ATP Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 31619474) Blood protein levels ( 30072576) Chronic kidney disease ( 29124443) Chronotype ( 30696823) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 26831199) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) Serum uric acid levels ( 30993211) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787)	Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)
Interacting Genes		6 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B INHBA INHBB	22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1
Entrez ID		3626	91
HPRD ID		03136	03193
Ensembl ID		ENSG00000175189	ENSG00000135503
Uniprot IDs		P55103	P36896
PDB IDs
Enriched GO Terms of Interacting Partners?
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