ACVR1B and TGFBRAP1

Data Source:
HPRD (in vivo)

		ACVR1B	TGFBRAP1
Description		activin A receptor type 1B	transforming growth factor beta receptor associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex	Cytoplasm Early Endosome Membrane CORVET Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Autophagy Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Endosomal Vesicle Fusion
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		ATP Fostamatinib
Diseases
GWAS		Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)	AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Gut microbiota relative abundance (Coprococcus) ( 33208821) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)
Interacting Genes		22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1	9 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A SMAD2 SMAD4 TGFBR1 TGFBR2
Entrez ID		91	9392
HPRD ID		03193	06948
Ensembl ID		ENSG00000135503	ENSG00000135966
Uniprot IDs		P36896	Q8WUH2
PDB IDs
Enriched GO Terms of Interacting Partners?
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