IMPDH1 and GMNN

Data Source:
BioGRID (two hybrid)

		IMPDH1	GMNN
Description		inosine monophosphate dehydrogenase 1	geminin DNA replication inhibitor
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS	CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148 Taribavirin
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Pelvic organ prolapse ( 32184442)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: DDIT4L GMNN HTRA1 IMPDH2 PIAS2 RAD54L2 RNF4 UBE2I	34 interacting genes: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 SAPCD2 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF250 ZNF439
Entrez ID		3614	51053
HPRD ID		08853	06783
Ensembl ID		ENSG00000106348	ENSG00000112312
Uniprot IDs		B3KRZ3 P20839 Q6ZNB1	A0A024QZY7 O75496
PDB IDs		1JCN	1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?
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