ILK and LIMS2

Data Source:
HPRD (in vivo, in vitro)

		ILK	LIMS2
Description		integrin linked kinase	LIM zinc finger domain containing 2
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GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Sarcomere Lamellipodium	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Metal Ion Binding
	Biological Process	Cell Morphogenesis Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling	Cell Junction Assembly Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Malaria ( 31844061)	Alzheimer's disease (cognitive decline) ( 23535033) Type 2 diabetes ( 25483131)
Interacting Genes		42 interacting genes: AKT1 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	17 interacting genes: APP CALCOCO2 GOLGA2 HIPK3 HRH1 ILK KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 LMNA MDFI MTUS2 NOTCH2NLA RCHY1 TRIM55 TRIM63
Entrez ID		3611	55679
HPRD ID		03842	06389
Ensembl ID		ENSG00000166333	ENSG00000072163
Uniprot IDs		Q13418 V9HWF0	A0A024RAH1 B3KNZ3 Q7Z4I7
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	3IXE
Enriched GO Terms of Interacting Partners?
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