LIMS2 and RCHY1

Data Source:
BioGRID (two hybrid)

		LIMS2	RCHY1
Description		LIM zinc finger domain containing 2	ring finger and CHY zinc finger domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Metal Ion Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Cell Junction Assembly Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis
Pathways		Cell-extracellular matrix interactions	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Type 2 diabetes ( 25483131)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		17 interacting genes: APP CALCOCO2 GOLGA2 HIPK3 HRH1 ILK KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 LMNA MDFI MTUS2 NOTCH2NLA RCHY1 TRIM55 TRIM63	75 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		55679	25898
HPRD ID		06389	07607
Ensembl ID		ENSG00000072163	ENSG00000163743
Uniprot IDs		A0A024RAH1 B3KNZ3 Q7Z4I7	Q96PM5
PDB IDs		3IXE	2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?
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