IL11 and IL11RA

Data Source:
HPRD (in vivo, in vitro)

		IL11	IL11RA
Description		interleukin 11	interleukin 11 receptor subunit alpha
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-11 Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Cytokine Binding Interleukin-11 Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Megakaryocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of MAPK Cascade Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs			Oprelvekin
Diseases
GWAS		Appendicular lean mass ( 33097823) Osteoarthritis (hip) ( 30374069) Response to antidepressants ( 20360315)	Blood protein levels ( 29875488) CTACK levels ( 27989323)
Interacting Genes		3 interacting genes: IL11RA MAGEA11 UBQLN2	2 interacting genes: IL11 OLFM4
Entrez ID		3589	3590
HPRD ID		00980	02965
Ensembl ID		ENSG00000095752	ENSG00000137070
Uniprot IDs		A8K3F7 P20809	Q14626 Q5VZ79
PDB IDs		4MHL 6O4O	6O4P
Enriched GO Terms of Interacting Partners?
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