IL4R and SOCS5

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		IL4R	SOCS5
Description		interleukin 4 receptor	suppressor of cytokine signaling 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Monocyte Chemotactic Protein-1 Production Vascular Endothelial Cell Response To Fluid Shear Stress
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling Neddylation
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Height ( 28552196 20881960) Offspring birth weight ( 31043758) Pulse pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	11 interacting genes: APP CASP3 EGFR ERBB2 ERBB3 ERBB4 IL4R KIT MET TMBIM1 UBC
Entrez ID		3566	9655
HPRD ID		00990	06159
Ensembl ID		ENSG00000077238	ENSG00000171150
Uniprot IDs		B2RBY1 P24394	O75159
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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