IL4R and IL13RA1

Data Source:
HPRD (in vitro, in vivo)

		IL4R	IL13RA1
Description		interleukin 4 receptor	interleukin 13 receptor subunit alpha 1
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GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab
Diseases		Asthma
GWAS		Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)	Body mass index ( 28892062) Type 2 diabetes ( 30718926)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	6 interacting genes: DLG4 IL13 IL4R TMEM39B TRAF3IP1 TYK2
Entrez ID		3566	3597
HPRD ID		00990	02125
Ensembl ID		ENSG00000077238	ENSG00000131724
Uniprot IDs		B2RBY1 P24394	P78552
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL	3BPN 3BPO 4HWB 5E4E
Enriched GO Terms of Interacting Partners?
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