IL3 and PIK3CD

Data Source:
HPRD (in vivo)

		IL3	PIK3CD
Description		interleukin 3	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
	Biological Process	MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Natural Killer Cell Differentiation Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling	PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib
Diseases
GWAS		Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		5 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD	15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 PIK3R3 RALY TAGLN TNPO2
Entrez ID		3562	5293
HPRD ID		00987	04161
Ensembl ID		ENSG00000164399	ENSG00000171608
Uniprot IDs		P08700	A0A2K8FKV1 O00329
PDB IDs		1JLI 5UV8 5UWC 6NMY	5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU
Enriched GO Terms of Interacting Partners?
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