IL2RB and MKKS

Data Source:
BioGRID (unspecified method)

		IL2RB	MKKS
Description		interleukin 2 receptor subunit beta	McKusick-Kaufman syndrome
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Cytoplasm Centrosome Cytosol Motile Cilium Kinociliary Basal Body
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding Unfolded Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly	Heart Looping Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Negative Regulation Of GTPase Activity Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Non-motile Cilium Assembly
Pathways		RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling	BBSome-mediated cargo-targeting to cilium
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases			46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS		Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13	4 interacting genes: APP CDR2 PTN ZBED1
Entrez ID		3560	8195
HPRD ID		00896	05356
Ensembl ID		ENSG00000100385	ENSG00000125863
Uniprot IDs		P14784	B7Z3W9 Q9NPJ1
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K
Enriched GO Terms of Interacting Partners?
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