LCE2C and PTPMT1

Data Source:
BioGRID (two hybrid)

		LCE2C	PTPMT1
Description		late cornified envelope 2C	protein tyrosine phosphatase mitochondrial 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatidylglycerophosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Keratinization	Cardiolipin Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Formation of the cornified envelope	Synthesis of PG
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Glomerular filtration rate ( 29403010) Hypertension ( 27618448) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean arterial pressure ( 27618448) Mood instability ( 31168069) Neuroticism ( 29255261) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		84 interacting genes: ADAMTSL4 ALPP C1orf94 CATSPER1 CCDC125 CHIC2 CRCT1 CREB5 CYP21A2 CYSRT1 EFEMP1 EFEMP2 EFNA3 FAM221B HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2D LCE3A LCE3B LCE3D LCE4A LCE5A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PCSK5 PIAS2 PTPMT1 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 TAP1 TGFB1 TM7SF2 TRIM42 UBE2I VASN VWC2 XAGE3	31 interacting genes: ADAMTSL4 CYSRT1 GRN KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-4 KRTAP3-1 KRTAP4-12 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE2C MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA RGS20 SIAH1 SSC4D TAB1 TMEM14B TRIM27
Entrez ID		353140	114971
HPRD ID		13972	15151
Ensembl ID		ENSG00000187180	ENSG00000110536
Uniprot IDs		Q5TA81	Q8WUK0
PDB IDs
Enriched GO Terms of Interacting Partners?
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