SP110 and NDUFV2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SP110	NDUFV2
Description		SP110 nuclear body protein	NADH:ubiquinone oxidoreductase core subunit V2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Viral Process	Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Mitochondrial Respiratory Chain Complex I Assembly Cardiac Muscle Tissue Development
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic lymphocytic leukemia ( 18758461 28165464 24292274) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Subcutaneous adipose tissue ( 26480920)	Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Platelet distribution width ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: ANXA7 CDKN1A NAP1L2 NDUFV2 OSGEP RUNX3 SMN1 TK1 TSC22D1 TTR ZSCAN9	6 interacting genes: CCNC CRMP1 FAM114A2 GOLM1 KAT5 SP110
Entrez ID		3431	4729
HPRD ID		06832	02757
Ensembl ID		ENSG00000135899	ENSG00000178127
Uniprot IDs		Q9HB58	P19404
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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