APOC1 and BCL2L2

Data Source:
BioGRID (two hybrid)

		APOC1	BCL2L2
Description		apolipoprotein C1	BCL2 like 2
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron	Mitochondrial Outer Membrane Bcl-2 Family Protein Complex
	Molecular Function	Phospholipase Inhibitor Activity Fatty Acid Binding Protein Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Disordered Domain Specific Binding
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Positive Regulation Of Cholesterol Esterification Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity	Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			Navitoclax
Diseases
GWAS		Alzheimer's disease ( 22832961 30636644 17998437 24755620) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease biomarkers ( 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Apolipoprotein Levels ( 23031429) Blood protein levels ( 29875488 28240269) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein ( 19567438) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Carotid intima media thickness ( 21909108) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebral cortex AV-45 amyloid PET measurement ( 31755389) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 30319691 28641921 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30319691 28641921) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 20686565) Cingulate cortical amyloid beta load ( 26421299) Cognitive impairment test score ( 30319691) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) HDL cholesterol ( 20686565) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 30718733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hippocampal atrophy rate ( 31760383) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) LDL cholesterol ( 18262040 18802019 18193043 18193044 20864672 26160806 19060906 20686565) LDL cholesterol levels ( 28334899 28371326) LDL cholesterol to HDL cholesterol ratio ( 28046027) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24023261) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302 20442857) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21740922) Low density lipoprotein cholesterol levels ( 28548082) Mean corpuscular hemoglobin concentration ( 32888494) Meat-related diet ( 32066663) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 31589552) Myocardial infarction ( 26343387) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Quantitative traits ( 19197348) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Resting heart rate ( 27798624) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 30275531 28548082) Triglyceride levels ( 32203549 28334899 31217584) Triglycerides ( 23726366 20686565) Type 2 diabetes ( 28869590) Verbal declarative memory ( 25648963)	Height ( 28552196)
Interacting Genes		30 interacting genes: ACACA ACSF2 APOA1 APOA2 ATP5MJ BCL2L2 CIDEB DBX1 DHRSX FOXD4L3 GSDMA H4C7 HIGD1C LETMD1 MAIP1 MICOS13 MPC2 MTCH2 MTERF3 NFU1 NSG2 RADIL RSAD2 RTP5 SIRPB1 SPG21 SYT16 TEX44 TPRG1 VKORC1	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		341	599
HPRD ID		00131	03569
Ensembl ID		ENSG00000130208	ENSG00000129473
Uniprot IDs		A0A024R0T8 P02654	Q92843
PDB IDs		1ALE 1ALF 1IOJ 1OPP 6DVU 6DXR 6DZ6 6NF3	1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
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