IAPP and RAMP2

Data Source:
HPRD (in vitro)

		IAPP	RAMP2
Description		islet amyloid polypeptide	receptor activity modifying protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Cell Surface Receptor Complex Amylin Receptor Complex 2 Adrenomedullin Receptor Complex
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Adrenomedullin Binding
	Biological Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein-containing Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Copper	Pramlintide
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Pulse pressure ( 30224653)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		3375	10266
HPRD ID		01005	05516
Ensembl ID		ENSG00000121351	ENSG00000131477
Uniprot IDs		A0A024RAU1 P10997	A0A024R1Z2 O60895
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR	2XVT 3AQE 3AQF 4RWF 6UUN 6V2E
Enriched GO Terms of Interacting Partners?
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