APLP2 and APBB1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro)

		APLP2	APBB1
Description		amyloid beta precursor like protein 2	amyloid beta precursor protein binding family B member 1
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Proline-rich Region Binding
	Biological Process	Platelet Degranulation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 29875488) Malaria ( 31844061)
Interacting Genes		23 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 VKORC1 ZNF512B	69 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ARF6 ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		334	322
HPRD ID		00103	04087
Ensembl ID		ENSG00000084234	ENSG00000166313
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481	B7Z4M9 O00213
PDB IDs		5JBT 5TPT	2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?
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