BIRC2 and HSP90B1

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		BIRC2	HSP90B1
Description		baculoviral IAP repeat containing 2	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Prostate cancer ( 23535732)	Blood protein levels ( 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		75 interacting genes: ABHD17A BIRC5 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	36 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CCT2 CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTEN PTPN11 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		329	7184
HPRD ID		03419	01860
Ensembl ID		ENSG00000110330	ENSG00000166598
Uniprot IDs		Q13490	P14625 V9HWP2
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR	4NH9
Enriched GO Terms of Interacting Partners?
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