BIRC2 and PCSK9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		BIRC2	PCSK9
Description		baculoviral IAP repeat containing 2	proprotein convertase subtilisin/kexin type 9
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GO Annotations	Cellular Component	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Endolysosome Membrane Perinuclear Region Of Cytoplasm PCSK9-LDLR Complex PCSK9-AnxA2 Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding	RNA Binding Serine-type Endopeptidase Activity Protein Binding Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Receptor Inhibitor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Protein Self-association Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Protein Polyubiquitination Response To Hypoxia Placenta Development MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Positive Regulation Of Receptor Internalization Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Signaling Receptor Activity Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Negative Regulation Of Signaling Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) VLDLR internalisation and degradation Post-translational protein phosphorylation LDL clearance
Drugs			Alirocumab Inclisiran
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Prostate cancer ( 23535732)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) LDL cholesterol ( 23726366 24097068 24507774 18193043 18193044 20864672 26160806 19060906 30275531 25961943 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 26690388 31087446 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Low density lipoprotein cholesterol levels ( 30718733 32154731) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Mitochondrial DNA copy number ( 30704525) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 26690388 31087446 29403010 30275531)
Interacting Genes		75 interacting genes: ABHD17A BIRC5 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W	3 interacting genes: BACE1 BIRC2 LDLR
Entrez ID		329	255738
HPRD ID		03419	07080
Ensembl ID		ENSG00000110330	ENSG00000169174
Uniprot IDs		Q13490	Q8NBP7
PDB IDs		1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR	2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R 4NE9 4NMX 4OV6 5OCA 5VL7 5VLA 5VLH 5VLK 5VLL 5VLP 6E4Y 6E4Z 6F5G 6MV5 6OLZ 6OM0 6OM7 6U26 6U2F 6U2N 6U2P 6U36 6U38 6U3I 6U3X
Enriched GO Terms of Interacting Partners?
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