APEH and IST1

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		APEH	IST1
Description		acylaminoacyl-peptide hydrolase	IST1 factor associated with ESCRT-III
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Nuclear Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body
	Molecular Function	RNA Binding Serine-type Endopeptidase Activity Protein Binding Omega Peptidase Activity Identical Protein Binding	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding
	Biological Process	Translational Termination Proteolysis Neutrophil Degranulation Amyloid-beta Metabolic Process	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly
Pathways		Neutrophil degranulation Eukaryotic Translation Termination	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Feeling tense ( 29500382) Feeling worry ( 29500382) Household income ( 31844048) Inflammatory bowel disease ( 28067908) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 21297633)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		5 interacting genes: IST1 LGALS8 SHBG TMEM62 UBA5	9 interacting genes: APEH ATXN1 BAG4 CAPN7 CHMP1A SPAST TOX3 UBQLN1 UBQLN2
Entrez ID		327	9798
HPRD ID		00034	13784
Ensembl ID		ENSG00000164062	ENSG00000182149
Uniprot IDs		P13798	B4DXC9 P53990
PDB IDs			3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA
Enriched GO Terms of Interacting Partners?
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