IST1 and CHMP1A

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IST1	CHMP1A
Description		IST1 factor associated with ESCRT-III	charged multivesicular body protein 1A
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GO Annotations	Cellular Component	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body	Condensed Nuclear Chromosome ESCRT III Complex Early Endosome Multivesicular Body Microtubule Organizing Center Endomembrane System Nuclear Matrix Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly	Proteolysis Nucleus Organization Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Gene Silencing Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Division Midbody Abscission Regulation Of Mitotic Spindle Assembly ESCRT III Complex Disassembly
Pathways		Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III	HCMV Late Events
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Estimated glomerular filtration rate ( 31152163) Hemoglobin levels ( 32327693) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Plasma homocysteine levels ( 30339177) Red vs. brown/black hair color ( 30531825)
Interacting Genes		9 interacting genes: APEH ATXN1 BAG4 CAPN7 CHMP1A SPAST TOX3 UBQLN1 UBQLN2	19 interacting genes: C14orf119 CHMP1B DDIT4L GORASP2 IST1 LNPK MITD1 NR1I2 PSMA1 SDCBP STAMBP TXN2 UBE2I USP8 VPS4A VPS4B VTA1 YES1 ZDHHC17
Entrez ID		9798	5119
HPRD ID		13784	01237
Ensembl ID		ENSG00000182149	ENSG00000131165
Uniprot IDs		B4DXC9 P53990	Q9HD42
PDB IDs		3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA	2JQ9 2YMB 4A5X
Enriched GO Terms of Interacting Partners?
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