HPCAL1 and CREM

Data Source:
BioGRID (two hybrid)

		HPCAL1	CREM
Description		hippocalcin like 1	cAMP responsive element modulator
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Chromatin Nucleus Transcription Regulator Complex Cytoplasm ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Calcium Ion Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Fatty Acid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Retinoic Acid Receptor Signaling Pathway Rhythmic Process
Pathways
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		38 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX
Entrez ID		3241	1390
HPRD ID		02564	00444
Ensembl ID		ENSG00000115756	ENSG00000095794
Uniprot IDs		O75544 P37235 Q6FGY1	Q03060
PDB IDs		5T7C
Enriched GO Terms of Interacting Partners?
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