HOXD4 and ETV4

Data Source:
BioGRID (two hybrid)

		HOXD4	ETV4
Description		homeobox D4	ETS variant transcription factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	MAPK6/MAPK4 signaling
Drugs
Diseases			Ewing's sarcoma Prostate cancer
GWAS		Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 28196072) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	14 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN MEOX2 SAE1 SMAD4 SRF STK11 UBA2
Entrez ID		3233	2118
HPRD ID		00864	02833
Ensembl ID		ENSG00000170166	ENSG00000175832
Uniprot IDs		P09016	P43268
PDB IDs			4CO8 4UUV 5ILU
Enriched GO Terms of Interacting Partners?
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