HOXC8 and RBCK1

Data Source:
BioGRID (two hybrid)

		HOXC8	RBCK1
Description		homeobox C8	RANBP2-type and C3HC4-type zinc finger containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Ubiquitin Ligase Complex Cytosol LUBAC Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Night sleep phenotypes ( 27126917)
Interacting Genes		107 interacting genes: ADAMTSL4 ANKS1A BLZF1 BMPR1A BTG2 C11orf1 C19orf54 C1orf109 CADPS CCM2 CEP70 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	65 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MALT1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		3224	10616
HPRD ID		00856	16643
Ensembl ID		ENSG00000037965	ENSG00000125826
Uniprot IDs		P31273	A6PVJ6 A6PVK0 Q9BYM8
PDB IDs			2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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